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Medical Decision Making
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Objective Criteria for In-vitro Responses in Human Tumor Colony-forming Assays

James A. Koziol

A. John Petkau

Raymond Taetle

The application of rigorous statistical criteria to the design and analysis of in-vitro assay techniques can lead to more reliable assessments of their utility. The authors demonstrate that an objective criterion for in-vitro drug sensitivity would yield less pronounced false- negative error rates than a fixed-cutoff rule, and would therefore be more suitable for screen ing of putative chemotherapeutic agents. Key words: drug sensitivity testing; objective criteria. (Med Decis Making 8:304-309, 1988)

Medical Decision Making, Vol. 8, No. 4, 304-309 (1988)
DOI: 10.1177/0272989X8800800411
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