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Medical Decision Making, Vol. 24, No. 5, 486-492 (2004)
DOI: 10.1177/0272989X04268953

The Cost-Effectiveness of Screening Programs Using Single and Multiple Birth Cohort Simulations: A Comparison Using a Model of Cervical Cancer

Sarah Dewilde, MSc

MEDTAP International® Inc., London, UK

Rob Anderson, PhD

CHERE, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australialia.

Despite early recognition of the theoretical advantages of simulations that include different population subgroups/ strata and different birth cohorts, manymodeling-based economic evaluations of cervical screening have been based on unrealistic single birth cohort simulations. The authors examined the effect of amultiple birth cohort simulation on the incremental cost-effectiveness estimates of cervical screening programs, compared to a conventional single cohort simulation. The choice of hypothetical cohort that starts the simulation had a major impact on the cost-effectiveness estimates: Compared with a single birth cohort simulation, the incremental cost-effectiveness of a shift from biennial to triennial screening was 30% higher when using the multiple cohort simulation. Multiple cohort simulations using the different age structures of 4 countries had little impact on the costeffectiveness ratios (variation <5%). Future modeling-based evaluations of screening policies should better reflect the age range of the population that is targeted by carefully specifying the nature of the starting cohort(s).

Key Words: cost-effectiveness • Markov model • cervical screening • cohort simulations


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