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Mapping the SF-12 to the EuroQol EQ-5D Index in a National US Sample

Center for Health Services Research in Primary Care, University of California, Davis

Erica I. Lubetkin, MD, MPH

Department of Community Health and Social Medicine, City University of New York Medical School, New York, New York

Marthe R. Gold, MD, MPH

Department of Community Health and Social Medicine, City University of New York Medical School, New York, New York

Daniel J. Tancredi, MS

Center for Health Services Research in Primary Care, University of California, Davis

Haomiao Jia, PhD

Department of Community Health and Social Medicine, City University of New York Medical School, New York, New York

Background. Preference scores for the Medical Outcomes Study (MOS) SF-12 would enable its use in cost-effectiveness analyses. Previous mapping studies of MOS instruments to preference-based instruments have not examined performance in national samples. Participants. 15,000 adults in the 2000 Medical Expenditure Panel Survey annual survey including the SF-12 and EQ-5D Index. Methods. Regression of the EQ-5D Index scores onto the physical and mental component summary scores of the SF-12, testing 2nd-4th degree polynomial and spline models, including and excluding sociodemographics. Results. A 2nd degree polynomial model explained 63% of the variance in EQ-5D scores, with robust internal and external validation. More complex models explained minimally additional variance. Compared with EQ-5D valuations, prediction models overestimated the lowest health states (6% of the population). Conclusions. The mapped SF-12 yields usable preference-scaled scores, with some caution for the lowest health states.

Key Words: health status • SF-12 • EQ-5D

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