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Comparison of Directly Elicited Preferences to Preferences Derived from the SF-36 in Adults with Asthma

Midwest Center for Health Ser- vices and Policy Research, Hines VA Hospital, Hines, IL, Center for Healthcare Studies, Northwestern University, Feinberg School of Medicine, Chicago, College of Pharmacy, University of Illinois at Chicago, lee{at}research.hines.med.va.gov

William Hollingworth, PhD

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (WH)

Sean D. Sullivan, PhD

Pharmaceutical Outcomes Research and Policy Program and the Departments of Pharmacy and Health Services, University of Washington, Seattle, WA

Introduction. Algorithms have been developed that estimate preferences from the Short Form 36 (SF-36). The objective of this study was to compare SF-36-derived preferences to directly elicited preferences. Methods. The authors used data from a clinical trial of adult asthmatics to derive preferences from the SF-36 and compare those to visual analog scale (VAS) values and the Asthma Quality-of-Life Questionnaire (AQLQ). Results. The differences between VAS and derived preferences ranged from -0.066 to 0.024 at baseline and 0.006 to 0.107 at the end of follow-up. All measures improved from baseline (P < 0.001); however, derived preferences un- derestimated change (0.066 to 0.131) compared to the VAS (0.173) (P < 0.001), which could affect economic evaluations. Correlations between preferences and the AQLQ ranged from 0.56 to 0.70 at baseline (P < 0.001) and 0.53to 0.70 for changes from baseline (P < 0.001). Conclusions. The derivation methods produce valid and responsive measures of patient preference. However, derived preferences differ from one another and directly elicited VAS preferences.

Key Words: visual analog scale • SF-36 • asthma • patient preference • preference derivation

Medical Decision Making, Vol. 23, No. 4, 323-334 (2003)
DOI: 10.1177/0272989X03256009


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