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Medical Decision Making
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Cost-Effectiveness of Pharmacological Interventions for Smoking Cessation: a Literature Review and a Decision Analytic Analysis

Fujian Song, PhD

Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham, UK f.song{at}bham.ac.uk

James Raftery, PhD

Health Services Management Centre, University of Birmingham, Birmingham, UK

Paul Aveyard, PhD

Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham, UK

Chris Hyde, MD

Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham, UK

Pelham Barton, PhD

Health Services Management Centre, University of Birmingham, Birmingham, UK

Nerys Woolacott, PhD

National Health Services Centre for Reviews and Dissemination, University of York, York, UK

To evaluate the relative cost-effectiveness of nicotine replacement therapy (NRT) and bupropion SR for smoking cessation, the authors reviewed published studies and developed a decision analytic model from the UK National Health Services perspective. Irrespective of the methods or assumptions involved, the results of published studies consistently indicated that NRT for smoking cessation is cost-effective. No published studies have evaluated the relative cost-effectiveness of bupropion SR for smoking cessation. The results of the decision analyses indicated that, as compared with advice or counseling alone, the incremental cost per life-years saved is about $1,441~$3,455 for NRT, $920~$2,150 for bupropion SR, and $1,282~$2,836 for NRT plus bupropion SR. The cost-effectiveness of adding NRT and bupropion SR to advice or counseling for smoking cessation is better than many other accepted health care interventions.

Key Words: decision analysis • cost-effectiveness • smoking cessation • nicotine replacement therapy (NRT) • bupropion SR

Medical Decision Making, Vol. 22, No. 5 suppl, S26-S37 (2002)
DOI: 10.1177/027298902237708
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