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Medical Decision Making
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What's this?

Bayesian Assessment of Sample Size for Clinical Trials of Cost-Effectiveness

Anthony O’Hagan

University of Sheffield, United Kingdom

John W. Stevens

AstraZeneca R&!D Charnwood, United Kingdom

The authors present an analysis of the choice of sample sizes for demonstrating cost-effectiveness of a new treatment or procedure, when data on both cost and efficacy will be collected in a clinical trial. The Bayesian approach to statistics is employed, as well as a novel Bayesian criterion that provides insight into the sample size problem and offers a very flexible formulation.

Key Words: Bayesian statistics • cost-effectiveness • experimental design • net benefits • pharmacoeconomics • sample size

Medical Decision Making, Vol. 21, No. 3, 219-230 (2001)
DOI: 10.1177/0272989X0102100307
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