This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Neumann, P. J. Articles by Weinstein, M. C. Search for Related Content PubMed PubMed Citation Articles by Neumann, P. J. Articles by Weinstein, M. C. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Alzheimer's Disease Social Bookmarking                   What's this?

A Comparison of HU12 and HU13 Utility Scores in Alzheimer's Disease

Address correspondence and reprint requests to Dr. Neumann: Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115. telephone: (617) 432-1312, fax: (617) 432-0190, e-mail. <pneumann{at}hsph.harvard.edu>

Eileen A. Sandberg, SM, MBA

Address correspondence and reprint requests to Dr. Neumann: Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115. telephone: (617) 432-1312, fax: (617) 432-0190, e-mail. <pneumann{at}hsph.harvard.edu>

Sally S. Araki, SM

Address correspondence and reprint requests to Dr. Neumann: Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115. telephone: (617) 432-1312, fax: (617) 432-0190, e-mail. <pneumann{at}hsph.harvard.edu>

Karen M. Kuntz, ScD

Address correspondence and reprint requests to Dr. Neumann: Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115. telephone: (617) 432-1312, fax: (617) 432-0190, e-mail. <pneumann{at}hsph.harvard.edu>

David Feeny, PhD

Address correspondence and reprint requests to Dr. Neumann: Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115. telephone: (617) 432-1312, fax: (617) 432-0190, e-mail. <pneumann{at}hsph.harvard.edu>

Milton C. Weinstein, PhD

Address correspondence and reprint requests to Dr. Neumann: Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115. telephone: (617) 432-1312, fax: (617) 432-0190, e-mail. <pneumann{at}hsph.harvard.edu>

Purpose. The Health Utilities Index (HUI) is a generic, multiattribute, preference-based health-status classification system. The HUI Mark 3 (HU13) differs from the earlier HUI2 by modifying attributes and allowing more flexibility for capturing high levels of impairment. The authors compared HUI2 and HU13 scores of patients with Alzheimer's disease (AD) and caregivers, and contrasted results of a cost-effectiveness analysis of new drugs for AD using the two systems. Methods. In a cross-sectional study of 679 AD patient/caregiver pairs, stratified by patient's disease stage (questionable/mild/moderate/severe/profound/terminal) and setting (community/assisted living/nursing home), caregivers completed the combined HU12/HU13 questionnaire as proxy respondents for patients and for themselves. Results. Mean (SD) global utility scores for patients were lower on the HU13 (0.22[0.26]) than on the HU12 (0.53 [0.21]). Patient HU13 utility scores ranged from 0.47(0.24) for questionable AD to -0.23 (0.08) for terminal AD, compared with a range of 0.73 (0.15) to 0.14 (0.07) for the HU12. Among the 203 patients in the severe, profound, and terminal stages, 96 (48%) had negative global HU13 utility scores, while none had a negative HU12 score. The utility scores for caregivers were similar on the HUI3 (0.87 [0.14]) and HU12 (0.87 [0.11]). Cost-effectiveness analysis of a new medication to treat AD showed somewhat more favorable results using the HU13. Conclusions. The HU12 and HU13 discriminate well across AD stages. Compared with the HU12, the HUI3 yields lower global utility scores for patients with AD, and more scores for states judged worse than dead. The HUI3 may yield substantially different results from the HU12, particularly for persons who have serious cognitive impairments such as AD. Key words: Health Utility Index; Alzheimer's disease ; utility assessment. (Med Decis Making 2000;20:413-422)

Medical Decision Making, Vol. 20, No. 4, 413-422 (2000)
DOI: 10.1177/0272989X0002000405


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. A. Rosenheck, D. L. Leslie, J. L. Sindelar, E. A. Miller, P. N. Tariot, K. S. Dagerman, S. M. Davis, B. D. Lebowitz, P. Rabins, J. K. Hsiao, et al. Cost-Benefit Analysis of Second-Generation Antipsychotics and Placebo in a Randomized Trial of the Treatment of Psychosis and Aggression in Alzheimer Disease Arch Gen Psychiatry, November 1, 2007; 64(11): 1259 - 1268. [Abstract] [Full Text] [PDF]

				B. G. Vickrey, B. S. Mittman, K. I. Connor, M. L. Pearson, R. D. Della Penna, T. G. Ganiats, R. W. DeMonte Jr., J. Chodosh, X. Cui, S. Vassar, et al. The Effect of a Disease Management Intervention on Quality and Outcomes of Dementia Care: A Randomized, Controlled Trial. Ann Intern Med, November 21, 2006; 145(10): 713 - 726. [Abstract] [Full Text] [PDF]

				H. McCarter, W. Furlong, A. C. Whitton, D. Feeny, S. DePauw, A. R. Willan, and R. D. Barr Health Status Measurements at Diagnosis As Predictors of Survival Among Adults With Brain Tumors J. Clin. Oncol., August 1, 2006; 24(22): 3636 - 3643. [Abstract] [Full Text] [PDF]

				S. N. Vigod and D. E. Stewart Major depression in female urinary incontinence. Psychosomatics, March 1, 2006; 47(2): 147 - 151. [Abstract] [Full Text] [PDF]

				C. W. Shepard, I. R. Ortega-Sanchez, R. D. Scott II, N. E. Rosenstein, and and the ABCs Team Cost-Effectiveness of Conjugate Meningococcal Vaccination Strategies in the United States Pediatrics, May 1, 2005; 115(5): 1220 - 1232. [Abstract] [Full Text] [PDF]

				S. L. Maddigan, D. H. Feeny, and J. A. Johnson A Comparison of the Health Utilities Indices Mark 2 and Mark 3 in Type 2 Diabetes Med Decis Making, November 1, 2003; 23(6): 489 - 501. [Abstract] [PDF]

				P. M. McMahon, S. S. Araki, E. A. Sandberg, P. J. Neumann, and G. S. Gazelle Cost-Effectiveness of PET in the Diagnosis of Alzheimer Disease Radiology, August 1, 2003; 228(2): 515 - 522. [Abstract] [Full Text] [PDF]

				J. L. Bosch, E. F. Halpern, and G. S. Gazelle Comparison of Preference-Based Utilities of the Short-Form 36 Health Survey and Health Utilities Index before and after Treatment of Patients with Intermittent Claudication Med Decis Making, October 1, 2002; 22(5): 403 - 409. [Abstract] [PDF]

				C. M. Bell, R. H. Chapman, P. W. Stone, E. A. Sandberg, and P. J. Neumann An Off-the-Shelf Help List: A Comprehensive Catalog of Preference Scores from Published Cost-Utility Analyses Med Decis Making, August 1, 2001; 21(4): 288 - 294. [Abstract] [PDF]