Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Medical Decision Making
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Pasta, D. J.
Right arrow Articles by Henning, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pasta, D. J.
Right arrow Articles by Henning, J. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Other

Probabilistic Sensitivity Analysis Incorporating the Bootstrap

An Example Comparing Treatments for the Eradication of Helicobacter pylori

David J. Pasta, MS

Jennifer L. Taylor

James M. Henning, MS

Decision-analytic models are frequently used to evaluate the relative costs and benefits of alternative therapeutic strategies for health care. Various types of sensitivity analysis are used to evaluate the uncertainty inherent in the models. Although probabilistic sensitivity analysis is more difficult theoretically and computationally, the results can be much more powerful and useful than deterministic sensitivity analysis. The authors show how a Monte Carlo simulation can be implemented using standard software to perform a probabilistic sensitivity analysis incorporating the bootstrap. The method is applied to a decision-analytic model evaluating the cost-effectiveness of Helicobacter pylori eradication. The necessary steps are straightforward and are described in detail. The use of the bootstrap avoids certain difficulties encountered with theoretical distri butions. The probabilistic sensitivity analysis provided insights into the decision-analytic model beyond the traditional base-case and deterministic sensitivity analyses and should become the standard method for assessing sensitivity. Key words: decision analysis; sensitivity analysis; decision trees; bootstrap; Monte Carlo; cost-effective ness ; sampling. (Med Decis Making 1999; 19:353-363)

Medical Decision Making, Vol. 19, No. 3, 353-363 (1999)
DOI: 10.1177/0272989X9901900314
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Circ Cardiovasc Qual OutcomesHome page
R. M. Merchant, L. B. Becker, B. S. Abella, D. A. Asch, and P. W. Groeneveld
Cost-Effectiveness of Therapeutic Hypothermia After Cardiac Arrest
Circ Cardiovasc Qual Outcomes, September 1, 2009; 2(5): 421 - 428.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. Choi, R. L. Sell, L. Lenert, P. Muennig, R. R. Goodman, F. G. Gilliam, and J. B. Wong
Epilepsy Surgery for Pharmacoresistant Temporal Lobe Epilepsy: A Decision Analysis
JAMA, December 3, 2008; 300(21): 2497 - 2505.
[Abstract] [Full Text] [PDF]

Home page
 Med Decis MakingHome page
G. B. Hazen and M. Huang
Large-Sample Bayesian Posterior Distributions for Probabilistic Sensitivity Analysis
Med Decis Making, September 1, 2006; 26(5): 512 - 534.
[Abstract] [PDF]

Home page
 The Annals of PharmacotherapyHome page
A. Berger, J. Edelsberg, T. T Li, J. R Maclean, and G. Oster
Dose Intensification with Infliximab in Patients with Rheumatoid Arthritis
Ann. Pharmacother., December 1, 2005; 39(12): 2021 - 2025.
[Abstract] [Full Text] [PDF]

Home page
 Decision AnalysisHome page
J. C. Felli and G. B. Hazen
Javelin Diagrams: A Graphical Tool for Probabilistic Sensitivity Analysis
Decision Analysis, June 1, 2004; 1(2): 93 - 107.
[Abstract] [PDF]

Home page
 Diabetes CareHome page
N. Aoki, K. Dunn, T. Fukui, J. R. Beck, W. J. Schull, and H. K. Li
Cost-Effectiveness Analysis of Telemedicine to Evaluate Diabetic Retinopathy in a Prison Population
Diabetes Care, May 1, 2004; 27(5): 1095 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 Med Decis MakingHome page
A. H. Briggs, R. Goeree, G. Blackhouse, and B. J. O'Brien
Probabilistic Analysis of Cost-Effectiveness Models: Choosing between Treatment Strategies for Gastroesophageal Reflux Disease
Med Decis Making, August 1, 2002; 22(4): 290 - 308.
[Abstract] [PDF]

Home page
 JAMAHome page
P. W. Groeneveld, J. L. Kwong, Y. Liu, A. J. Rodriguez, M. P. Jones, G. D. Sanders, and A. M. Garber
Cost-effectiveness of Automated External Defibrillators on Airlines
JAMA, September 26, 2001; 286(12): 1482 - 1489.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
J. B. Wong and R. S. Koff
Watchful Waiting with Periodic Liver Biopsy versus Immediate Empirical Therapy for Histologically Mild Chronic Hepatitis C: A Cost-Effectiveness Analysis
Ann Intern Med, November 7, 2000; 133(9): 665 - 675.
[Abstract] [Full Text] [PDF]