This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Unic, I. Articles by Van Daal, W. A.J. Search for Related Content PubMed PubMed Citation Articles by Unic, I. Articles by Van Daal, W. A.J. Social Bookmarking                   What's this?

Assessment of the Time-tradeoff Val ues for Prophylactic Mastectomy of Women with a Suspected Genetic Predisposition to Breast Cancer

Peep F.M. Stalmeier

Lia C.G. Verhoef

Willem A.J. Van Daal

Background. Female carriers of the breast-cancer-susceptibility genes BRCA1 and BRCA2 are at high risk for breast cancer (85%). They face the choice between pro phylactic mastectomy (PM) and breast cancer screening. For this treatment choice, a shared-decision-making program was developed. In this program, the time tradeoff (TTO) was used to assess preferences for PM. Purpose. Assessment of the feasibility, constant proportional tradeoff, and reliability of using the TTO for this purpose. Meth ods. Fifty-four women suspected to carry the BRCA1/2 mutation were provided with comprehensive relevant information. Their preferences for PM were assessed on two occasions. Discrepancies between preferences indicated by the two tests were re solved by testing a third time. The preferences assessed on the last occasion were used for individual decision analyses. In order to test constant proportional tradeoff, the TTO consisted of four items with different numbers of life years. Results. Forty- two women (78%) completed the TTO twice and nine women (17%) performed the test a third time. Three women (5%) completed the TTO only once. The mean TTO value for PM at the last replication was 0.69 (SD = 0.30). Violations of constant pro portional tradeoff were significant: the largest tradeoffs were recorded for the shortest durations. Pearson's correlation coefficient between the TTO values for the two last sessions was 0.96. Conclusion. Assessment of individual preferences by the TTO in this patient group is feasible and reliable. Therefore, the TTO can be used in clinical settings to elicit treatment preferences of women proven or suspected to have a ge netic predisposition to breast cancer. Key words: shared decision making; breast can cer ; prophylactic mastectomy; preference assessment; time tradeoff; genetic predis position. (Med Decis Making 1998;18:268-277)

Medical Decision Making, Vol. 18, No. 3, 268-277 (1998)
DOI: 10.1177/0272989X9801800303


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. Tsuchiya and P. Dolan The QALY Model and Individual Preferences for Health States and Health Profiles over Time: A Systematic Review of the Literature Med Decis Making, July 1, 2005; 25(4): 460 - 467. [Abstract] [PDF]

				M. Locadia, P. F. M. Stalmeier, F. J. Oort, M. H. Prins, M. A. G. Sprangers, and P. M. M. Bossuyt A Comparison of 3 Valuation Methods for Temporary Health States in Patients Treated with Oral Anticoagulants Med Decis Making, November 1, 2004; 24(6): 625 - 633. [Abstract] [PDF]

				M.S. van Roosmalen, P.F.M. Stalmeier, L.C.G. Verhoef, J.E.H.M. Hoekstra-Weebers, J.C. Oosterwijk, N. Hoogerbrugge, U. Moog, and W.A.J. van Daal Randomized Trial of a Shared Decision-Making Intervention Consisting of Trade-Offs and Individualized Treatment Information for BRCA1/2 Mutation Carriers J. Clin. Oncol., August 15, 2004; 22(16): 3293 - 3301. [Abstract] [Full Text] [PDF]

				P. F. M. Stalmeier Discrepancies between Chained and Classic Utilities Induced by Anchoring with Occasional Adjustments Med Decis Making, February 1, 2002; 22(1): 53 - 64. [Abstract] [PDF]

				W. Sumner II and R. F. Nease Jr. Choice-Matching Preference Reversals in Health Outcome Assessments Med Decis Making, May 1, 2001; 21(3): 208 - 218. [Abstract] [PDF]

				I. Unic, L. C.G. Verhoef, P. F.M. Stalmeier, and W. A.J. Van Daal Prophylactic Mastectomy or Screening in Women Suspected to Have the BRCA1/2 Mutation: A Prospective Pilot Study of Women's Treatment Choices and Medical and Decision-analytic Recommendations Med Decis Making, July 1, 2000; 20(3): 251 - 262. [Abstract] [PDF]

				P. F.M. Stalmeier, I. J. Unic, L. C.G. Verhoef, and W. A.J. Van Daal Evaluation of a Shared Decision Making Program for Women Suspected to Have a Genetic Predisposition to Breast Cancer: Preliminary Results Med Decis Making, August 1, 1999; 19(3): 230 - 241. [Abstract] [PDF]